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1994-06-12
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Document 0301
DOCN M9460301
TI [Adjuvant corticoid administration within the scope of HIV disease.
Indications in wasting syndrome and other diseases within the scope of
AIDS]
DT 9408
AU Jager H; KIS-Kuratorium fur Immunschwache, Munchen.
SO Fortschr Med. 1994 Mar 10;112(7):87-91. Unique Identifier : AIDSLINE
MED/94229699
AB While at the start of the AIDS epidemic, corticosteroids were considered
to be contraindicated, about 10 indications have since been identified
for the specific use of glucocorticoids in HIV infection. Some of these
indications have already been confirmed in controlled scientific
studies, for example, pneumocystis carinii pneumonia or HIV-induced
high-grade non-Hodgkin's lymphoma. In the case of other indications, for
example, cerebral toxoplasmosis or certain forms of the wasting
syndrome, clinical observational studies and, in particular, empirical
data provided by large groups working on AIDS, are available. The use of
corticoids for such other indications as pulmonary involvement in the
case of Kaposi's sarcoma, or thrombopenia in HIV patients, is still
experimental. To date, the initially feared high rate of side effects
due to the theoretically possible impairment of immunological function,
has not been observed. The effect of the corticosteroids appears to be
concentrated more in their anti-inflammatory action than in substitution
in the event of adrenal insufficiency. The carefully considered and
selective use of corticosteroids can both improve the quality of life
and lengthen the life expectancy of many HIV victims.
DE Adrenal Cortex Hormones/*ADMINISTRATION & DOSAGE/ADVERSE EFFECTS/
CONTRAINDICATIONS AIDS-Related Opportunistic Infections/*DRUG THERAPY
Cachexia/*DRUG THERAPY Dose-Response Relationship, Drug Drug
Administration Schedule English Abstract
Glucocorticoids/ADMINISTRATION & DOSAGE/ADVERSE EFFECTS/
CONTRAINDICATIONS Human HIV Infections/*DRUG THERAPY JOURNAL ARTICLE
REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).